Pharmacy Technician

1. A drug with a large apparent volume of distribution (> 100 L) is most likely:

2. Phase I metabolic reactions most often involve:

3. The primary site of drug excretion for polar water-soluble metabolites is the:

4. Which mechanism is most common for drug molecules crossing lipid membranes?

5. A drug’s ability to cross the blood–brain barrier depends primarily on:

6. Bioavailability (F) is defined as the fraction of an administered dose that:

7. Which physiological barrier is most restrictive to drug movement?

8. The “first-pass effect” refers to drug loss during:

9. Which is a parenteral route of administration?

10. A pharmacological receptor may include:

11. Which branch of pharmacology studies the effects of drugs on receptors and physiological functions?

12. Ligand-gated ion channel receptors directly regulate:

13. Sublingual administration:

14. Apparent volume of distribution (Vd) is calculated by:

15. Which route of drug administration is classified as enteral?

16. Endocytosis and exocytosis are used to transport:

17. Sublingual administration:

18.
1. Pharmacokinetics primarily describes:

19. Which family of receptors uses a seven–transmembrane domain linked to a G-protein?

20. First-pass hepatic metabolism most profoundly reduces the bioavailability of drugs given via the:

21. Which factor does NOT significantly modify drug absorption?

22. Pharmacodynamics is best described as the study of:

23. Active transport of drugs across membranes requires:

24. Enzyme-linked receptors often possess:

25. Which of the following best defines pharmacology?

26. Phase II metabolism typically results in:

27. An example of “other” routes of administration is:

28. The primary organ for drug metabolism is the:

29. The half-life of a drug is the time required for its plasma concentration to fall by:

30. Intracellular receptors for drugs are most likely to:

31. Which route accounts for significant drug excretion of volatile anesthetics?

32. Drug absorption is defined as the transfer of a drug from its site of administration into:

33. Which process is most responsible for reabsorption of lipid-soluble drugs in the kidney?

34. Drugs bound to plasma proteins are:

35. Which tissue has the lowest rate of drug distribution based on blood flow?

36. A major disadvantage of the oral route is: